[Association between methylthioadenosine phosphorylase gene single nucleotide polymorphisms and myocardial infarction in Chinese Han ethnicity].

Abstract

OBJECTIVE:

To investigate the association between methylthioadenosine phosphorylase (MTAP) gene single nucleotide polymorphisms (SNP) and myocardial infarction (MI) in the Chinese Han ethnicity.

METHODS:

432 patients suffered from myocardial infarction and 430 controls were involved for case and control groups, respectively. Nine tag SNPs in MTAP gene were selected and genotyped.

RESULTS:

We found no significant association of selected tag SNPs with MI in all of the samples. However, in stratified analysis, significant association was observed at rs7027989 in male subjects. The risk of MI increased by 26% (P = 0.005) for male subjects of minor allele carriers in a dominant model. The increased risk of MI at rs7027989 remained significant after adjusting for confounding factors.

CONCLUSION:

MTAP gene might be involved in the etiology of MI in Chinese Han ethnicity.

• Authors: Qi Zhang, Shuang-shuang Cheng, Jie Yan, Xing-dong Chen, Xiao-feng Wang, Xin-chun Yang
• Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi (Zhonghua Liu Xing Bing Xue Za Zhi) Vol. 31 Issue 1 Pg. 83-6 (Jan 2010) ISSN: 0254-6450 [Print] China
• PMID: 20302706 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Purine-Nucleoside Phosphorylase
• 5'-methylthioadenosine phosphorylase

Topics

• Adult
• Aged
• Alleles
• Asian People (genetics)
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Middle Aged
• Myocardial Infarction (genetics)
• Polymorphism, Single Nucleotide
• Purine-Nucleoside Phosphorylase (genetics)