The proportion of free PSA and upgrading of biopsy Gleason score after radical prostatectomy.

Abstract

INTRODUCTION:

Upgrading of biopsy Gleason score (GS) after radical prostatectomy (RP) to GS >or=7 is common in patients with low-grade prostate cancer in biopsy. We evaluated whether a low proportion of free PSA (%fPSA) and total PSA (tPSA) predict significant upgrading after RP.

PATIENTS AND METHODS:

122 patients with biopsy GS 5 or 6 prostate cancer and a tPSA <10 ng/ml who underwent RP in our academic center were included in the study. The utility of prebiopsy %fPSA and tPSA as predictors of significant upgrading was evaluated.

RESULTS:

Among patients undergoing RP, upgrading to GS >or=7 was found in 61 of 122 (50%) patients. A low %fPSA was a predictor of significant upgrading of tumors with biopsy GS 5 or 6 prostate cancer in patients with tPSA <10 ng/ml.

CONCLUSIONS:

Our results suggest that the selection of prostate cancer patients for active surveillance or re-biopsy may be improved by using %fPSA as a predictor of significant upgrading.

• Authors: Harri Visapää, Kristina Hotakainen, Johan Lundin, Martti Ala-Opas, Ulf-Håkan Stenman
• Journal: Urologia internationalis (Urol Int) Vol. 84 Issue 4 Pg. 378-81 ( 2010) ISSN: 1423-0399 [Electronic] Switzerland
• PMID: 20299777 (Publication Type: Journal Article)
• Copyright: Copyright (c) 2010 S. Karger AG, Basel.

Chemical References

• Prostate-Specific Antigen

Topics

• Biopsy
• Chi-Square Distribution
• Finland
• Humans
• Logistic Models
• Male
• Neoplasm Staging
• Predictive Value of Tests
• Prostate-Specific Antigen (blood)
• Prostatectomy
• Prostatic Neoplasms (immunology, pathology, surgery)
• Retrospective Studies
• Risk Assessment
• Risk Factors
• Treatment Outcome