Abstract | BACKGROUND: Pigment lasers have been used in melasma with unsatisfactory results. OBJECTIVE: MATERIALS AND METHODS: Split-face randomized study comparing combination QS- Nd:YAG laser and 2% hydroquinone with topical treatment in dermal or mixed-type melasma. Twenty-two patients were treated with 1,064-nm QS- Nd:YAG laser, 6-mm spot size, 3.0- to 3.8-J/cm(2) fluence for five sessions at 1-week intervals. Pigmentation was objectively recorded using a colorimeter (lightness index score), and subjective assessments were evaluated using the modified Melasma Area and Severity Index (mMASI) score. RESULTS: After five laser treatments, statistically significant improvement of melasma from baseline was observed in colorimeter (p<.001) and mMASI score (p<.001) on the laser side. The laser side achieved an average 92.5% improvement in relative lightness index and 75.9% improvement in mMASI, compared with 19.7% and 24%, respectively, on the control side (p<.001). Mottled hypopigmentation developed in three patients. During follow-up, four of 22 patients developed rebound hyperpigmentation, and all patients had recurrence of melasma. CONCLUSION:
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Authors | Penpun Wattanakrai, Ratchathorn Mornchan, Sasima Eimpunth |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 36
Issue 1
Pg. 76-87
( 2010)
ISSN: 1524-4725 [Electronic] United States |
PMID | 20298254
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Dermatologic Agents
- Hydroquinones
- hydroquinone
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Topics |
- Administration, Topical
- Adult
- Asian People
- Combined Modality Therapy
- Dermatologic Agents
(administration & dosage)
- Female
- Humans
- Hydroquinones
(administration & dosage)
- Lasers, Solid-State
- Low-Level Light Therapy
- Male
- Melanosis
(therapy)
- Middle Aged
- Skin
(drug effects, radiation effects)
- Skin Pigmentation
(drug effects, radiation effects)
- Treatment Outcome
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