Microsatellite polymorphisms in intron 2 of the toll-like receptor 2 gene and their association with susceptibility to pulmonary tuberculosis in Han Chinese.
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| Abstract | BACKGROUND:
Toll-like receptor 2 (TLR2) is essential for the immune response to tuberculosis (TB). The goal of the present study was to investigate whether the guanine-thymine (GT) repeat microsatellite polymorphism in intron 2 of the TLR2 gene might be correlated with susceptibility to TB in Han Chinese. METHODS: The number of (GT)n repeats was determined by gene scanning from 244 patients with TB and 233 control subjects. The expression of TLR2 on CD14+ peripheral blood mononuclear cells was determined using flow cytometry. RESULTS: No association in allelic polymorphism between control subjects and patients with TB was found. However, the S/M genotype of the microsatellite polymorphism was more frequent in TB patients than in healthy controls (p=0.01). The S/L genotype was more popular in controls than in patients with TB (p=0.007). TLR2 expression was higher in subjects with the S/L genotype than in those with the S/M genotype (p<0.05). CONCLUSIONS: Our data suggest that the S/M genotype of the microsatellite (GT)n polymorphisms in intron 2 of the TLR2 gene may increase susceptibility to TB in Chinese, and the S/L genotype may act as a negative risk factor.
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| Authors | Yun Xue, Lei Jin, A-Zhong Li, Hua-Jun Wang, Meng Li, Yu-Xiang Zhang, Yu Wang, Ji-Cheng Li |
| Journal | Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 48 Issue 6 Pg. 785-9 (Jun 2010) ISSN: 1437-4331 [Electronic] Germany |
| PMID | 20298136 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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