| Abstract | The purpose of the present study was to quantify the rates of production and to define the mechanism(s) or origin of sex steroid hormones in a 3 1/2-year-old girl with isosexual precocious pseudopuberty caused by a granulosa-theca cell tumor of the ovary. The results suggest that the hyperestrogenism occurs principally due to the secretion of estradiol-17beta synthesized de novo by the tumor, but that the tumor in vivo was also capable of aromatizing C19 plasma precursor hormones to estrogen. |
| Authors | J D Madden, P C MacDonald |
| Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 51
Issue 2
Pg. 210-3
(Feb 1978)
ISSN: 0029-7844 UNITED STATES |
| PMID | 202898
(Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
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| Topics |
- Child, Preschool
- Estrogens
(metabolism)
- Female
- Granulosa Cell Tumor
(complications, metabolism, pathology)
- Humans
- Ovarian Neoplasms
(complications, metabolism, pathology)
- Puberty, Precocious
(etiology, metabolism, pathology)
- Thecoma
(complications, metabolism, pathology)
|
