Inhibition of growth and pulmonary metastasis of B16-F10 murine melanoma by N-1554, a polyprenyl phosphate.

Abstract

Antitumor effect of N-1554 (alpha-dihydrodecaprenyl phosphate containing eight trans internal isoprene residues) against B16-F10 melanoma in syngeneic C57BL/6 mice was examined. B16-F10 cells were inoculated into the footpad of mice and N-1554 was intraperitoneally administered after the inoculation. The drug significantly inhibited the tumor growth in the footpad and dramatically reduced the pulmonary metastasis from the tumor. The antitumor effect of N-1554 was almost abolished when the immunosuppressant carrageenan or anti-asialo GM1 antibody was administered to mice. In addition, pretreatment of host mice with N-1554 reduced the growth of subcutaneously inoculated B16-F10 melanoma. These results suggest that enhancement of host immune system may be involved in the antitumor effect of N-1554.

• Authors: Y Okamoto, T Ohwaki, S Kawase, Y Ishii, T Hongyo, Y Tahara, Y Mishima
• Journal: Cancer letters (Cancer Lett) Vol. 57 Issue 2 Pg. 159-63 (May 01 1991) ISSN: 0304-3835 [Print] Ireland
• PMID: 2025888 (Publication Type: Journal Article)

Chemical References

• Antibodies
• Antineoplastic Agents
• Glycosphingolipids
• Polyisoprenyl Phosphates
• G(M1) Ganglioside
• asialo GM1 ganglioside
• Carrageenan
• dihydrodecaprenyl phosphate

Topics

• Animals
• Antibodies (pharmacology)
• Antineoplastic Agents
• Carrageenan (pharmacology)
• Cell Line
• G(M1) Ganglioside
• Glycosphingolipids (immunology)
• Lung Neoplasms (prevention & control, secondary)
• Male
• Melanoma (drug therapy, pathology)
• Mice
• Mice, Inbred C57BL
• Polyisoprenyl Phosphates (administration & dosage, antagonists & inhibitors, therapeutic use)