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Effect of 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea on experimental tumors.

Abstract
A newly synthesized water-soluble nitrosourea derivative, 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea (GANU; NSC-254157) has marked activities against experimental tumors such as lymphoid leukemia L-1210, ascites sarcoma- 180, ascites hepatoma AH-130, and Walker carcinosarcoma-256. A single intraperitoneal injection of the compound is more effective than successive injections on the L-1210 system. An especially interesting point is that both the single intraperitoneal and single oral administrations 2 days after tumor implantation showed a high effectiveness. In addition, growth of the mammary adenocarcinoma transplanted subcutaneously on the back of mice was also considerably suppressed by successive intraperitoneal injections of the compound.
AuthorsT Hisamatsu, S Uchida
JournalGan (Gan) Vol. 68 Issue 6 Pg. 819-24 (Dec 1977) ISSN: 0016-450X [Print] Japan
PMID202535 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Nitrosourea Compounds
  • Ethyl Chloride
  • GANU
  • Streptozocin
Topics
  • Adenocarcinoma (drug therapy)
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Carcinoma 256, Walker (drug therapy)
  • Carcinoma, Hepatocellular (drug therapy)
  • Ethyl Chloride (analogs & derivatives, therapeutic use)
  • Female
  • Leukemia L1210 (drug therapy)
  • Leukemia, Experimental (drug therapy)
  • Liver Neoplasms
  • Male
  • Mammary Neoplasms, Experimental (drug therapy)
  • Mice
  • Neoplasms, Experimental (drug therapy)
  • Nitrosourea Compounds (therapeutic use)
  • Sarcoma 180 (drug therapy)
  • Streptozocin (analogs & derivatives)

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