5-Isopropylidene-3-ethyl rhodanine induce growth inhibition followed by apoptosis in leukemia cells.

Abstract

5-Isopropylidene-3-ethyl rhodanine II was prepared by conventional and Microwave assisted synthesis. For the first time, we found that rhodanine II treatment led to cytotoxicity in leukemic cell line, CEM by inducing apoptosis.

• Authors: Subban Ravi, Kishore K Chiruvella, K Rajesh, V Prabhu, Sathees C Raghavan
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 45 Issue 7 Pg. 2748-52 (Jul 2010) ISSN: 1768-3254 [Electronic] France
• PMID: 20236736 (Publication Type: Journal Article)
• Copyright: Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• 5-isopropylidene-3-ethyl rhodanine
• Rhodanine

Topics

• Apoptosis (drug effects)
• Cell Cycle (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Flow Cytometry
• Humans
• Leukemia (pathology)
• Rhodanine (analogs & derivatives, chemical synthesis, chemistry, pharmacology)
• Time Factors