Abstract |
Mycoplasmas, which lack a cell wall and are the smallest self-replicating bacteria, have been linked to some chronic diseases, such as AIDS, rheumatoid arthritis (RA), and oncogenic transformation of cells. Their membrane components ( lipoproteins and glycolipids) have been identified as possible causative factors in such diseases. Glycoglycerophospholipid ( GGPL)-III, a unique phosphocholine-containing aminoglycoglycerophospholipid, is a major specific antigen of Mycoplasma fermentans, and has been detected in 38% of RA patients. Unlike those of lipoproteins, which induce inflammation via Toll-like receptor 2 (TLR2), the pathologic effects of GGPL-III are poorly understood. RA and metal allergies are chronic inflammatory diseases in which autoantigens have been implicated. Here, we examined the effects of chemically synthesized GGPL-III in murine arthritis and allergy models. GGPL-III alone exhibited little inflammatory effect, but promoted both collagen-induced arthritis and nickel (Ni) allergy, although less powerfully than Escherichia coli lipopolysaccharide. The augmenting effect of GGPL-III on Ni allergy was present in mice deficient in either T cells or active TLR4, but it was markedly weaker in mice deficient in macrophages, interleukin-1, or the histamine-forming enzyme histidine decarboxylase than in their control strains. These results suggest that GGPL-III may play roles in some types of chronic diseases via the innate immune system.
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Authors | Naoki Sato, Takefumi Oizumi, Masayuki Kinbara, Tadasu Sato, Hiromi Funayama, Seiji Sato, Kazuhiro Matsuda, Haruhiko Takada, Shunji Sugawara, Yasuo Endo |
Journal | FEMS immunology and medical microbiology
(FEMS Immunol Med Microbiol)
Vol. 59
Issue 1
Pg. 33-41
(Jun 01 2010)
ISSN: 1574-695X [Electronic] England |
PMID | 20236320
(Publication Type: Journal Article)
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Chemical References |
- 1''-phosphocholine-2''-aminodihydroxypropane-3''-phospho-6'-glucopyranosyl-(1'-3)-1,2-dipalmitoylglycerol
- Allergens
- Antigens, Bacterial
- Glycolipids
- Interleukin-1
- Lipopolysaccharides
- Tlr4 protein, mouse
- Toll-Like Receptor 4
- Nickel
- Collagen
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Topics |
- Allergens
(immunology)
- Animals
- Antigens, Bacterial
(immunology)
- Arthritis
(chemically induced, immunology)
- Collagen
(immunology)
- Disease Models, Animal
- Escherichia coli
(chemistry, immunology)
- Glycolipids
(chemical synthesis, immunology)
- Hypersensitivity
(immunology)
- Interleukin-1
(deficiency, immunology)
- Lipopolysaccharides
(immunology, isolation & purification)
- Macrophages
(immunology)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred DBA
- Mice, Knockout
- Mycoplasma fermentans
(chemistry, immunology)
- Nickel
(immunology)
- T-Lymphocytes
(immunology)
- Toll-Like Receptor 4
(deficiency, immunology)
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