Abstract | BACKGROUND AND PURPOSE: OBJECTIVE: To investigate the relationship between the presence and severity of leukoaraiosis on baseline CT and the risk of sICH and functional outcome after tPA treatment for acute ischaemic stroke. METHODS: A single-center observational cohort study with a retrospective analysis on consecutive patients with ischaemic stroke treated with tPA in the period 2002-2008. Outcome measures were the occurrence of sICH and functional outcome at 3 months. RESULTS: Of the 400 patients, 24% had leukoaraiosis on their baseline CT. Eleven patients (11%) with leukoaraiosis versus thirteen (4%) patients without leukoaraiosis had a sICH [odds ratio (OR) 2.85 95%-CI 1.23-6.60, P = 0.02]. Multivariate analysis showed a non-significant trend towards an association of leukoaraiosis and sICH (OR 1.9, 95%-CI 0.78-4.68, P = 0.16). Leukoaraiosis was independently associated with poor functional outcome (OR 2.39, 95%-CI 1.21-4.72, P = 0.01). No difference was observed in the outcome measures amongst patients with moderate or severe leukoaraiosis. CONCLUSION: Our study demonstrates that patients treated with tPA and leukoaraiosis on their baseline CT are at greater risk of sICH and have a worse functional outcome compared to patients without leukoaraiosis. It is important to note that these results should not lead to exclusion of patients with leukoaraiosis for tPA treatment.
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Authors | M J H Ariës, M Uyttenboogaart, P C Vroomen, J De Keyser, G J Luijckx |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 17
Issue 6
Pg. 866-70
(Jun 01 2010)
ISSN: 1468-1331 [Electronic] England |
PMID | 20236179
(Publication Type: Journal Article)
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Chemical References |
- Fibrinolytic Agents
- Tissue Plasminogen Activator
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Topics |
- Aged
- Cerebral Hemorrhage
(chemically induced)
- Cohort Studies
- Female
- Fibrinolytic Agents
(adverse effects)
- Humans
- Leukoaraiosis
(complications)
- Male
- Middle Aged
- Stroke
(complications, drug therapy)
- Tissue Plasminogen Activator
(adverse effects)
- Tomography, X-Ray Computed
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