In vivo experimental approach to treatment against tabun poisoning.
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| Abstract |
Organophosphorus compounds pose a potential threat to both military and civilian populations. Since post-exposure therapy has its limitations, our research was focused on the possibility of improving pretreatment in order to limit the toxic effects of tabun. We determined the protective index of various combinations of atropine, oximes (K074, K048, and TMB-4), and pyridostigmine given to mice before tabun intoxication. Although the tested oximes showed very good therapeutic efficacy in tabun-poisoned mice, the given pretreatments improved therapy against tabun poisoning. These regimens ensured survival of all animals up to 25.2 LD(50) of tabun. Our results indicate that even pretreatment with atropine alone is sufficiently effective in enhancing the survival of mice poisoned by multiple doses of tabun, if oxime therapy follows. K048 is our oxime of choice for future research, as it shows better protective and reactivating potency.
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| Authors | Suzana Berend, Maja Katalinić, Ana Lucić Vrdoljak, Zrinka Kovarik, Kamil Kuca, Bozica Radić |
| Journal | Journal of enzyme inhibition and medicinal chemistry (J Enzyme Inhib Med Chem) Vol. 25 Issue 4 Pg. 531-6 (Aug 2010) ISSN: 1475-6374 [Electronic] England |
| PMID | 20235800 (Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
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