The prognostic value of the temporal course of S100beta protein in post-acute severe brain injury: A prospective and observational study.

To study the predictive capacity of early S100beta samples for long-term outcome prediction after severe TBI.
Eighty-seven patients with severe TBI were studied. Clinical and CT scan were taken at admission. S100beta concentration was quantified at admission and 24, 48 and 72 hours post-TBI (days 0, 1, 2 and 3). Outcome was assessed 12 months after discharge using Glasgow Outcome Score (GOS).
Significant negative correlations were found between 1-year GOS and S100beta concentrations on days 1-3, but not on day 0. Deceased patients showed higher S100beta concentration than survivors on days 1-3. Good (GOS = 4-5) vs poor outcome (GOS = 1-3) differed significantly on day 3. Death outcome was independently predicted by day 2 (>2.37 microg l(-1)), day 3 (>1.41 microg l(-1)) samples and absence of pupillary reaction. Poor outcome was predicted independently only by pupillary reaction and the 72-hour sample (>1.1 microg l(-1)), but this predictive model was less satisfactory than the predictive model for death.
A temporal profile of S100beta release from admission to 72 hours post-TBI is strongly recommended for use in identifying patients at risk of developing a worse outcome. The S100beta protein might be an early biomarker for predicting long-term outcome in patients with acute severe TBI.
AuthorsFrancisco Murillo-Cabezas, Maria Angeles Muñoz-Sánchez, Maria Dolores Rincón-Ferrari, Juan Francisco Martín-Rodríguez, Rosario Amaya-Villar, Susana García-Gómez, José León-Carrión
JournalBrain injury (Brain Inj) Vol. 24 Issue 4 Pg. 609-19 ( 2010) ISSN: 1362-301X [Electronic] England
PMID20235763 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
  • Adolescent
  • Adult
  • Aged
  • Biomarkers (metabolism)
  • Brain Injuries (metabolism, physiopathology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Growth Factors (metabolism)
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • Quality of Life
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins (metabolism)
  • Survivors
  • Time Factors
  • Young Adult

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