(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).

Abstract	Enantiomerically pure cyclopentyl cytosine [(-)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine, (+/-)-carbodine and ribavirin. (-)-Carbodine 1 exhibited potent antiviral activity against various strains of influenza A and B viruses.
Authors	Jagadeeshwar R Rao, Ashok K Jha, Ravindra K Rawal, Ashoke Sharon, Craig W Day, Dale L Barnard, Donald F Smee, Chung K Chu
Journal	Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 20 Issue 8 Pg. 2601-4 (Apr 15 2010) ISSN: 1464-3405 [Electronic] England
PMID	20231094 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Copyright	Copyright 2010 Elsevier Ltd. All rights reserved.
Chemical References	Antiviral Agents Cytidine carbodine
Topics	Animals Antiviral Agents (chemical synthesis, chemistry, pharmacology) Cell Line Cytidine (analogs & derivatives, chemical synthesis, chemistry, pharmacology) Dogs Influenza A Virus, H1N1 Subtype (drug effects) Influenza A Virus, H5N1 Subtype (drug effects) Serial Passage Stereoisomerism

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