HLA-B27-associated bilateral Ménière disease.

Abstract

We describe 2 cases of bilateral Ménière disease with features resembling autoimmune inner ear disease in patients who were found to be carriers of human leukocyte antigen (HLA) B27. For immunohistochemical analysis, mouse inner ear sections were used as the tissue substrate for reaction with serum. Both patients demonstrated an increased immunofluorescence reaction compared with a normal control. We suggest that an antibody-mediated mechanism may be responsible for HLA-B27-associated Ménière disease.

• Authors: Shamila G Rawal, Kunal H Thakkar, Kasra Ziai, Peter A Santi, Hamid R Djalilian
• Journal: Ear, nose, & throat journal (Ear Nose Throat J) Vol. 89 Issue 3 Pg. 122-7 (Mar 2010) ISSN: 1942-7522 [Electronic] United States
• PMID: 20229477 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• HLA-B27 Antigen
• Dexamethasone
• Prednisone

Topics

• Administration, Topical
• Aged
• Alleles
• Anti-Inflammatory Agents (therapeutic use)
• Dexamethasone (therapeutic use)
• Genotype
• HLA-B27 Antigen (genetics)
• Hearing Loss, Bilateral (diagnosis, etiology)
• Humans
• Male
• Meniere Disease (complications, drug therapy, genetics)
• Middle Aged
• Prednisone (therapeutic use)
• Severity of Illness Index
• Vertigo (diagnosis, etiology)