Antitumor activity of the immunomodulatory lead Cumaside.

Abstract

A new immunomodulatory lead Cumaside that is a complex of monosulfated triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol possesses significantly less cytotoxic activity against sea urchin embryos and Ehrlich carcinoma cells than the corresponding glycosides. Nevertheless Cumaside has an antitumor activity against different forms of experimental mouse Ehrlich carcinoma in vivo both independently and in combination with cytostatics. The highest effect occurs at a treatment once a day for 7 days before the tumor inoculation followed by Cumaside treatment once a day for 7 days. Prophylactic treatment with Cumaside and subsequent therapeutic application of 5-fluorouracil suppressed the tumor growth by 43%.

• Authors: D L Aminin, E L Chaykina, I G Agafonova, S A Avilov, V I Kalinin, V A Stonik
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 10 Issue 6 Pg. 648-54 (Jun 2010) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 20227525 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents
• Glycosides
• Immunologic Factors
• Saponins
• Triterpenes
• cucumarioside A2-2
• cumaside
• Cholesterol
• Fluorouracil

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology, therapeutic use)
• Carcinoma, Ehrlich Tumor (drug therapy)
• Cell Line, Tumor
• Cholesterol (analogs & derivatives, chemistry, therapeutic use)
• Female
• Fluorouracil (therapeutic use)
• Glycosides (chemistry, therapeutic use)
• Immunologic Factors (chemistry, pharmacology, therapeutic use)
• Male
• Mice
• Saponins (therapeutic use)
• Triterpenes (chemistry, therapeutic use)