Acetazolamide improves cerebral hemodynamics in CADASIL.

Abstract

BACKGROUND:

Acetazolamide (ACZ), a carbonic anhydrase inhibitor, causes a rapid increase in cerebral blood flow (CBF) in patients with cerebrovascular diseases. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebrovascular disease caused by mutations in the NOTCH3 gene. Recent studies suggest that ACZ infusion significantly increases cerebral perfusion, even within areas of impaired cerebral vasoreactivity in CADASIL patients. This study evaluates the efficacy and tolerance of a 24-week treatment with 250 mg/d ACZ, which could be chronically implemented to improve cerebral hemodynamics in CADASIL.

METHODS:

CADASIL patients (n=16) were treated with ACZ (250 mg) daily for 24 weeks. The mean blood flow velocity (MFV) of the middle cerebral artery (MCA) and CO(2)-induced cerebrovascular reactivity (CVR) were tested using transcranial Doppler sonography (TCD) before and after treatment.

RESULTS:

After ACZ treatment, the MFV in the MCA was significantly greater at rest (57.68+/-12.7 cm/s versus 67.12+/-9.4 cm/s; P=0.001). Additionally, the CO(2)-induced vasoreactivity increased significantly (13.17+/- 6.9% versus 20.69+/-8.2%, P=0.004), and the pulsatility index (PI) decreased significantly (0.82+/-0.1 versus 0.73+/-0.08; P=0.001). The relative ACZ-induced enhancement of CO(2) vasoreactivity was not correlated with pretreatment MFV (SRCC=-0.122; P=0.659).

CONCLUSIONS:

The present study provides the first evidence that ACZ therapy can increase CBF and CVR in CADASIL patients.

• Authors: Li Huang, Qidong Yang, Le Zhang, Xuan Chen, Qing Huang, Hongxing Wang
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 292 Issue 1-2 Pg. 77-80 (May 15 2010) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 20227091 (Publication Type: Journal Article)
• Copyright: Copyright 2010 Elsevier B.V. All rights reserved.

Chemical References

• Carbonic Anhydrase Inhibitors
• Acetazolamide

Topics

• Acetazolamide (therapeutic use)
• Adult
• Blood Flow Velocity (drug effects)
• CADASIL (diagnostic imaging, drug therapy)
• Carbonic Anhydrase Inhibitors (therapeutic use)
• Cerebrovascular Circulation (drug effects)
• Female
• Hemodynamics (drug effects)
• Humans
• Longitudinal Studies
• Male
• Middle Aged
• Middle Cerebral Artery (diagnostic imaging, drug effects)
• Patient Selection
• Pilot Projects
• Treatment Outcome
• Ultrasonography