HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Brainstem mechanisms of amylin-induced anorexia.

Abstract
Amylin is secreted by pancreatic beta-cells and is believed to be a physiological signal of satiation. Amylin's effect on eating has been shown to be mediated via a direct action at the area postrema (AP) via amylin receptors that are heterodimers of the calcitonin receptor core protein with a receptor activity modifying protein. Peripheral amylin leads to accumulation of cyclic guanosine monophosphate, phosphorylated extracellular-signal regulated kinase 1/2 and c-Fos protein in AP neurons. The particular amylin-activated AP neurons mediating its anorexigenic action seem to be noradrenergic. The central pathways mediating amylin's effects have been characterized by lesioning and tracing studies, identifying important connections from the AP to the nucleus of the solitary tract and lateral parabrachial nucleus. Amylin was shown to interact, probably at the brainstem, with other signals involved in the short term control of food intake, namely cholecystokinin, glucagon-like peptide 1 and peptide YY. Amylin also interacts with the adiposity signal leptin; this interaction, which is thought to involve the hypothalamus, may have important implications for the development of new and improved hormonal obesity treatments. In conclusion, amylin actions on food intake seem to reside primarily within the brainstem, and the associated mechanisms are starting to be unraveled. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009.
AuthorsCatarina Soares Potes, Thomas Alexander Lutz
JournalPhysiology & behavior (Physiol Behav) Vol. 100 Issue 5 Pg. 511-8 (Jul 14 2010) ISSN: 1873-507X [Electronic] United States
PMID20226802 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Copyright2010 Elsevier Inc. All rights reserved.
Chemical References
  • Amyloid
  • Appetite Depressants
  • Islet Amyloid Polypeptide
Topics
  • Amyloid (adverse effects)
  • Animals
  • Anorexia (chemically induced)
  • Appetite Depressants (adverse effects)
  • Brain Stem (cytology, drug effects, physiology)
  • Eating (drug effects)
  • Humans
  • Islet Amyloid Polypeptide
  • Neurons (drug effects)
  • Signal Transduction (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: