[Two cases of MPO-ANCA-positive otitis media associated with facial palsy].

Abstract

We report two cases of otitis media positive for antimyeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) associated with facial palsy. Case 1: A 73-year-old man treated for 3 months for bilateral otitis media with effusion had left facial nerve palsy and deteriorated bone conduction hearing in both ears. Blood analysis showed elevated MPO-ANCA to 134 EU. Case 2: A 66-year-old woman treated for about one year for bilateral otitis media with effusion and fluctuating mixed hearing loss had bilateral facial nerve palsy and a blood test positive for MPO-ANCA at 67 EU. Both were diagnosed with otitis media caused by ANCA-related vasculitis. After prednisolone and cyclophosphamide administration for half a year, blood test results were negative for MPO-ANCA. Both recovered almost completely from facial nerve palsy and bone conductive hearing loss partially improved except in one hearing-impaired ear. ANCA-related vasculitis of the temporal bone should thus be considered in those with intractable otitis media and deteriorated bone conduction hearing before the occurrence of facial palsy.

• Authors: Hajime Usubuchi, Kozue Kodama, Katsumi Takizawa, Takeharu Kanazawa, Yasushi Ohta, Keiko Kakizaki, Yukiko Iino
• Journal: Nihon Jibiinkoka Gakkai kaiho (Nihon Jibiinkoka Gakkai Kaiho) Vol. 113 Issue 2 Pg. 67-71 (Feb 2010) ISSN: 0030-6622 [Print] Japan
• PMID: 20225706 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Peroxidase

Topics

• Aged
• Antibodies, Antineutrophil Cytoplasmic (blood)
• Facial Paralysis (complications)
• Female
• Humans
• Male
• Otitis Media (complications, immunology)
• Peroxidase (immunology)