Abstract | OBJECTIVE: The aim of the study was to evaluate whether the visual analysis of muscle magnetic resonance imaging scans can identify specific patterns of muscle involvement. METHODS: RESULTS: In 82% of the scans in the study group (68/83) the patterns were classified as "typical" of 1 of the 5 forms studied, and in 7 (8%) were consistent with 1 of the reported patterns but not entirely typical. With one exception, the patterns identified were always consistent with the appropriate genetic diagnosis. The remaining scans (9%) had only minimal changes and were uninformative. None of the scans of the 25 patients in the control group had patterns that could be classified as typical of the 5 forms examined. The sensitivity to detect selective patterns in relation to the genetic diagnosis was 0.9. INTERPRETATION: These findings suggest that muscle magnetic resonance imaging could be used in clinical practice as an additional tool in the differential diagnosis of muscle disorders with prominent spinal rigidity.
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Authors | Eugenio Mercuri, Emma Clements, Amaka Offiah, Anna Pichiecchio, Gessica Vasco, Flaviana Bianco, Angela Berardinelli, Adnan Manzur, Marika Pane, Sonia Messina, Francesca Gualandi, Enzo Ricci, Mary Rutherford, Francesco Muntoni |
Journal | Annals of neurology
(Ann Neurol)
Vol. 67
Issue 2
Pg. 201-8
(Feb 2010)
ISSN: 1531-8249 [Electronic] United States |
PMID | 20225280
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Collagen Type XI
- Muscle Proteins
- SELENON protein, human
- Selenoproteins
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- Collagen Type XI
(genetics)
- Female
- Humans
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Muscle Proteins
(genetics)
- Muscle, Skeletal
(pathology)
- Muscular Dystrophies
(classification, complications, genetics, pathology)
- Selenoproteins
(genetics)
- Sensitivity and Specificity
- Spinal Diseases
(etiology, pathology)
- Young Adult
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