Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia.

Abstract

Myasthenia gravis (MG) is an antibody and complement mediated autoimmune disease. Serum CXC chemokine ligand 13 (CXCL13) was found to be elevated in MG patients and high CXCL13 level was associated with severe clinical stages, especially in females with thymic lymphoid hyperplasia. Both protein and mRNA of CXCL13 and CXC chemokine receptor 5 (CXCR5) in the thymic tissues were significantly higher in MG patients with lymphoid hyperplasia than those with thymoma. Our data indicated that serum CXCL13 can be used as an index of disease severity and ectopic thymic expression of CXCL13 might be associated with aberrant cell trafficking to the thymus of MG.

• Authors: Yu-Ming Shiao, Chin-Cheng Lee, Yung-Hsiang Hsu, Shiu-Feng Huang, Chung-Yen Lin, Ling-Hui Li, Cathy S-J Fann, Chang-Youh Tsai, Shih-Feng Tsai, Hou-Chang Chiu
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 221 Issue 1-2 Pg. 101-6 (Apr 15 2010) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 20223524 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier B.V. All rights reserved.

Chemical References

• CXCR5 protein, human
• Chemokine CXCL13
• RNA, Messenger
• Receptors, CXCR5

Topics

• Adult
• Aged
• Aged, 80 and over
• Chemokine CXCL13 (genetics, metabolism)
• Enzyme-Linked Immunosorbent Assay (methods)
• Female
• Gene Expression Regulation (immunology)
• Humans
• Immunotherapy (methods)
• Male
• Middle Aged
• Myasthenia Gravis (complications, metabolism, pathology, therapy)
• RNA, Messenger (metabolism)
• Receptors, CXCR5 (genetics, metabolism)
• Sex Factors
• Thymus Gland (immunology, metabolism)
• Thymus Hyperplasia (complications, metabolism, pathology)
• Young Adult