Abstract |
The effects of nilvadipine, a Ca2+ entry blocker, on focal cerebral ischemia were investigated in rats having unilateral middle cerebral artery occlusion. All rats had 24 h ischemia, and were divided into three groups (ten rats per group). Groups 1 and 2 received 1.0 and 3.2 mg/kg nilvadipine s.c. respectively, just after the occlusion. Control rats received an equal volume of the vehicle. Control animals had a % infarct volume of 28.2 +/- 11.4%, and a left/right hemispheric volume ratio of 112 +/- 12%. Group-1 and -2 rats had % infarct volumes of 25.5 +/- 11.6% and 13.9 +/- 9.2% (p less than 0.01) respectively, and left/right hemispheric volume ratios of 111 +/- 9% and 103 +/- 7% (p less than 0.05), respectively. Thus, the drug reduced the infarct size and the brain edema in a dose-dependent manner. The significant decrease in the infarct volume was observed in the periphery of the frontoparietal cortex. This study supports the hypothesis that nilvadipine may be a potential therapeutic agent for cerebral ischemia. Neuropathological findings suggest the possible therapeutic effects of the drug in the ischemic penumbra.
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Authors | S Kawamura, N Yasui, M Shirasawa, H Fukasawa |
Journal | Experimental brain research
(Exp Brain Res)
Vol. 83
Issue 2
Pg. 434-8
( 1991)
ISSN: 0014-4819 [Print] Germany |
PMID | 2022249
(Publication Type: Journal Article)
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Chemical References |
- Calcium Channel Blockers
- nilvadipine
- Nifedipine
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Topics |
- Acute Disease
- Animals
- Brain
(pathology)
- Brain Edema
(prevention & control)
- Brain Ischemia
(drug therapy, pathology, physiopathology)
- Calcium Channel Blockers
(therapeutic use)
- Cerebral Infarction
(prevention & control)
- Male
- Nifedipine
(analogs & derivatives, therapeutic use)
- Rats
- Rats, Inbred Strains
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