HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intraoperative defect in haemostasis in a child receiving valproic acid.

Abstract
This report describes the development of an intraoperative defect in haemostasis which occurred during surgery for lengthening of the heel cords and release of hip contractures in a patient receiving valproic acid. A review of the literature failed to find any other cases of a valproic acid-induced bleeding disorder occurring under anaesthesia and surgery. While recognized in the non-surgical literature, this case reports the first in which the development of a valproic acid-induced haemostatic defect occurred under anaesthesia. The subsequent course is discussed and some pathophysiological mechanisms are presented. It is suggested that for patients receiving valproic acid preoperative education should include PT/PTT, platelet and fibrinogen counts and bleeding time so that abnormal coagulation states can be recognized.
AuthorsJ E Tetzlaff
JournalCanadian journal of anaesthesia = Journal canadien d'anesthesie (Can J Anaesth) Vol. 38 Issue 2 Pg. 222-4 (Mar 1991) ISSN: 0832-610X [Print] United States
PMID2021993 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Valproic Acid
Topics
  • Child
  • Hemostasis, Surgical
  • Humans
  • Intraoperative Period
  • Male
  • Seizures (complications, drug therapy)
  • Valproic Acid (adverse effects, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: