[Antiviral properties of analogs of distamycin A].

Abstract

The effect of 9 analogues of distamycin A was studied in a tissue culture with respect to the virus of a smallpox vaccine and classical avian plague. Three analogues of distamycin A (I, VI, VII) were studied in chick embryos with respect to the smallpox and influenza viruses. The analogues were characterized by a loss or decrease of the activity against the smallpox vaccine virus as compared to distamycin A. In contrast to distamycin A analogue VII had an inhibitory effect on influenza infection in chick embryos.

• Authors: T Ia Goncharskaia, S M Navashin, S L Grokhovskiĭ, A L Zhuze
• Journal: Antibiotiki (Antibiotiki) Vol. 22 Issue 11 Pg. 998-1002 (Nov 1977) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Izuchenie protivovirusnykh svoĭstv analogov distamitsina A.
• PMID: 202191 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Distamycins
• Pyrroles

Topics

• Antiviral Agents
• Distamycins (pharmacology)
• Influenza A virus (drug effects)
• Orthomyxoviridae (drug effects)
• Pyrroles (pharmacology)
• Variola virus (drug effects)