Comparative study of two mechlorethamine, vincristine, procarbazine, and prednisone derived chemotherapeutic protocols for the management of pediatric Hodgkin lymphoma (HL): single-center 5-year experience.
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| Abstract |
We aimed for the comparison of two protocols (OAP and COMP) as chemotherapy treatment in children with Hodgkin lymphoma (HL). A total of 119 children newly diagnosed with HD were divided to receive either the anthracycline-based OAP protocol or the alkylating-agent-based COMP protocol. Sixty patients received the OAP protocol and 59 patients received the COMP protocol. Complete response was achieved for 81.4% of patients treated with the COMP protocol versus 53.3% for those who received the OAP treatment. Toxic hepatitis or liver cell failure was recorded in 5% of patients treated with the COMP protocol. Complications were more frequent in those treated with the OAP protocol, as 6.8% developed heart failure and 20% showed toxic hepatitis or liver cell failure. The relapse rate was almost equal in both treatment arms. Patients treated with the COMP protocol achieved a better response and less toxicity but with similar survival to those given the OAP protocol.
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| Authors | Youssef Al-Tonbary, Mohamed M Sarhan, Rasha A El-Ashry, Emad Salama, Mohamed Sedki, Ashraf Fouda |
| Journal | Leukemia & lymphoma (Leuk Lymphoma) Vol. 51 Issue 4 Pg. 656-63 (Apr 2010) ISSN: 1029-2403 [Electronic] United States |
| PMID | 20218813 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial) |
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