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Effects of hypocapnia on spontaneous burst activity in the piriform-amygdala complex of newborn rat brain preparations in vitro.

Abstract
We examined effects of hypocapnia on burst activity in the piriform-amygdala complex and C(4) inspiratory activity in limbic-brainstem-spinal cord preparations from 0- to 1-day-old rats. Hypocapnia (2% CO(2)) increased the burst rate in the piriform-amygdala complex but decreased the C(4) inspiratory burst rate. Since hyperventilation induces hypocapnia, and enhanced amygdala activity may be involved in induction of a sense of anxiety, our findings might explain the neuronal mechanism of a vicious circle between hyperventilation and an increased sense of anxiety.
AuthorsT Fujii, H Onimaru, M Suganuma, I Homma
JournalAdvances in experimental medicine and biology (Adv Exp Med Biol) Vol. 669 Pg. 333-6 ( 2010) ISSN: 0065-2598 [Print] United States
PMID20217377 (Publication Type: Journal Article)
Topics
  • Amygdala (physiopathology)
  • Animals
  • Animals, Newborn
  • Anxiety (physiopathology, psychology)
  • Brain Stem (physiopathology)
  • Hyperventilation (physiopathology, psychology)
  • Hypocapnia (physiopathology, psychology)
  • Inhalation
  • Rats
  • Rats, Wistar
  • Spinal Cord (physiopathology)

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