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Fungal toxins and multiple sclerosis: a compelling connection.

Abstract
Multiple sclerosis occurs as a consequence of central nervous system neuronal demyelination. Decades of research suggest that the primary suspects (e.g., viruses, genes, immune system) are associative rather than causative agents, but a surprisingly coherent relationship can be made between multiple sclerosis and fungal toxins. Specifically, certain pathogenic fungi sequester in non-neuronal tissue and release toxins that target and destroy CNS astrocytes and oligodendrocytes. Without these glial support cells, myelin degrades triggering the onset of multiple sclerosis and its associated symptoms. We propose here that fungal toxins are the underlying cause of multiple sclerosis and thus may offer an avenue towards an effective cure.
AuthorsCatherine B Purzycki, Daniel H Shain
JournalBrain research bulletin (Brain Res Bull) Vol. 82 Issue 1-2 Pg. 4-6 (Apr 29 2010) ISSN: 1873-2747 [Electronic] United States
PMID20214953 (Publication Type: Journal Article, Review)
CopyrightCopyright 2010 Elsevier Inc. All rights reserved.
Chemical References
  • Mycotoxins
Topics
  • Animals
  • Fungi (pathogenicity)
  • Humans
  • Multiple Sclerosis (immunology, microbiology, pathology)
  • Mycotoxins (immunology, toxicity)
  • Neuroglia (drug effects, microbiology)

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