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Anti-ischemic and anti-inflammatory activity of (S)-cis-verbenol.

Abstract
(S)-cis-verbenol, a natural metabolite from (-)-alpha-pinene of host pine tree, has been suggested to have anti-ischemic activity. However, the exact mechanism for the anti-ischemic activity of (S)-cis-verbenol remains unclear yet. In the present study, (S)-cis-verbenol reduced cerebral ischemic injury caused by 1.5-h middle cerebral artery occlusion followed by 24-h reperfusion. Furthermore, (S)-cis-verbenol significantly prevented neuronal cell death caused by oxygen-glucose deprivation (OGD, 1 h) and subsequent re-oxygenation (5 h). While (S)-cis-verbenol did not inhibit the NMDA-stimulated calcium influx, it reduced the intracellular level of reactive oxygen species (ROS) elevated by OGD/re-oxygenation. ORAC assay indicated that (S)-cis-verbenol potently eliminated peroxyl radicals. In DPPH and DHR123 fluorescence assays, however, (S)-cis-verbenol did not show a direct ROS scavenging effect. Furthermore, (S)-cis-verbenol reduced the expression levels of pro-inflammatory cytokines in ischemic brain and immunostimulated glial cells. The present results indicate that (S)-cis-verbenol may be a useful therapeutic agent due to its anti-oxidative and anti-inflammatory activities.
AuthorsIn-Young Choi, Ji H Lim, Sunyoung Hwang, Jae-Chul Lee, Geum-Sil Cho, Won-Ki Kim
JournalFree radical research (Free Radic Res) Vol. 44 Issue 5 Pg. 541-51 (May 2010) ISSN: 1029-2470 [Electronic] England
PMID20214504 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Bicyclic Monoterpenes
  • Cytokines
  • Monoterpenes
  • Reactive Oxygen Species
  • verbenol
  • Glucose
  • Oxygen
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (chemistry, pharmacology)
  • Antioxidants (chemistry, pharmacology)
  • Bicyclic Monoterpenes
  • Brain Ischemia (drug therapy, metabolism, pathology)
  • Cell Death (drug effects)
  • Cytokines (biosynthesis, drug effects)
  • Dose-Response Relationship, Drug
  • Glucose (metabolism)
  • Male
  • Monoterpenes (chemistry, pharmacology)
  • Neuroglia (drug effects, metabolism)
  • Neurons (drug effects, pathology)
  • Oxygen (metabolism)
  • Rats
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species (metabolism)
  • Stereoisomerism

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