[CIinical study on treatment of Leber hereditary optic neuropathy].

Abstract

OBJECTIVE:

To investigate the effect of Wuzi Yanzong Decoction (WYD) in treating Leber hereditary optic neuropathy (LHON).

METHODS:

Thirty patients of LHON up to the requirement were assigned to two groups, the treated group administered with WYD plus coenzyme Q10, and the control group with coenzyme Q10 alone, all for 3 months. Patients' visual acuity, visual field, vision evoked potential (VEP) and their Chinese medicine syndrome were observed before and after treatment.

RESULTS:

After treatment, all the above-mentioned indexes were improved to some extents in the treated group, but showed no evident change in the control group excepting visual acuity, comparison between groups showed the differences were significant in all items.

CONCLUSION:

WYD shows certain clinical therapeutic effect for treatment of LHON.

• Authors: Cheng-wu Li, Zeng-yuan Zhuang, Shou-kang Zhang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 29 Issue 12 Pg. 1078-80 (Dec 2009) ISSN: 1003-5370 [Print] China
• PMID: 20214326 (Publication Type: Controlled Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• wuzi yanzong
• Ubiquinone
• coenzyme Q10

Topics

• Adolescent
• Adult
• Drugs, Chinese Herbal (therapeutic use)
• Evoked Potentials, Visual
• Female
• Humans
• Male
• Optic Atrophy, Hereditary, Leber (drug therapy, genetics)
• Phytotherapy
• Ubiquinone (analogs & derivatives, therapeutic use)
• Visual Acuity
• Young Adult