Comparative efficacy and safety results of topical hemostatic powder and sterile compressed foam sponge in second intention healing following Mohs micrographic surgery.

Abstract

This study compared the safety and efficacy of a non-prescription topical hemostatic powder (THP) containing a hydrophilic polymer and a potassium-based salt (group 1) to a sterile, compressed surgical sponge (group 2) for second intention healing (SIH) in 24 subjects following Mohs micrographic surgery (MMS) for the removal of non-melanoma skin cancers of the head and neck with a final defect size of 0.5 mm-2.0 cm. At least 50% of the subjects were receiving ongoing anti-coagulants. Hemostasis, rate of healing, wound size, global assessments of healing and application-site reactions were assessed. Time to hemostasis was measured at the time of surgery. Group 1 achieved hemostasis at a median of 52.5 seconds after the first stage of MMS versus 60 seconds in group 2. By week 12, wound size was reduced by a median of 182 mm2 in group 1 and 161.5 mm2 in group 2. A case series of subjects treated with THP following 4-mm punch biopsies is also discussed.

• Authors: Leon Kircik, James Q Del Rosso
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 9 Issue 2 Pg. 137-40 (Feb 2010) ISSN: 1545-9616 [Print] United States
• PMID: 20214176 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Hemostatics
• Powders

Topics

• Administration, Topical
• Female
• Hemostatics (administration & dosage, adverse effects)
• Humans
• Male
• Mohs Surgery
• Powders
• Sterilization
• Surgical Sponges
• Wound Healing