Intravitreal ranibizumab for choroidal neovascularization associated with retinal astrocytic hamartoma.

Abstract

PURPOSE:

To report on a patient with retinal astrocytic hamartoma, who developed a choroidal neovascularization (CNV), effectively treated by intravitreal ranibizumab injections.

METHODS:

A 74-year-old woman who, 12 years before, had been diagnosed with a yellow-gray lesion in the left eye (OS) presented in our department for OS decreased vision of recent onset.

RESULTS:

Upon a complete ophthalmologic examination including ultrasonography, fluorescein angiography (FA), and spectral domain optical coherence tomography (SD-OCT), the patient was diagnosed with retinal astrocytic hamartoma and coincident CNV on its foveal border. Six months after 3 monthly intravitreal ranibizumab injections, FA and OCT revealed the CNV closure and absence of intraretinal and subretinal fluid on the foveal border of the retinal astrocytic hamartoma.

CONCLUSIONS:

Associations between retinal astrocytic hamartoma and CNV have not been previously reported. Intravitreal ranibizumab injection appears an attractive therapeutic option for patients showing such an unusual association.

• Authors: Giuseppe Querques, Houda Kerrate, Nicolas Leveziel, Gabriel Coscas, Gisele Soubrane, Eric H Souied
• Journal: European journal of ophthalmology (Eur J Ophthalmol) 2010 Jul-Aug Vol. 20 Issue 4 Pg. 789-91 ISSN: 1120-6721 [Print] United States
• PMID: 20213614 (Publication Type: Case Reports, Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Ranibizumab

Topics

• Aged
• Angiogenesis Inhibitors (administration & dosage)
• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Humanized
• Choroidal Neovascularization (diagnosis, drug therapy, etiology)
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Hamartoma (complications, diagnosis)
• Humans
• Intravitreal Injections
• Ranibizumab
• Retinal Diseases (complications, diagnosis)
• Tomography, Optical Coherence
• Visual Acuity