Efficacy of clorsulon for the treatment of experimentally induced infections of Fasciola hepatica in goats.

Abstract

A dose titration study was undertaken to determine the efficacy of clorsulon against the adult stage of Fasciola hepatica in goats. Thirty-nine goats were experimentally infected with metacercariae of F hepatica. At 14 weeks after infection, each goat was assigned randomly to 1 of 5 groups. Goats in groups 1 to 4 received a single oral administration of clorsulon at dosages of 3.5, 7, 11, and 15 mg/kg of body weight, respectively. The fifth group of goats (control group) was infected with F hepatica, but were not treated with clorsulon. Postmortem examination of goats at 3 weeks after treatment revealed mean reductions in numbers of flukes of 83, 98, 99, and 100% for groups 1 to 4, respectively. Mean percentage of reduction in eggs following treatment of groups was 82, 98, 100, and 100%, respectively. The clinical effects of clorsulon in 24 goats that were not infected with F hepatica were studied. Goats in groups 1 to 3 received a single oral administration of clorsulon at dosages of 7, 21, and 35 mg/kg, respectively, every other day for a total of 3 doses/goat. Group-4 goats (control group) received a vehicle placebo. Goats in group 3 were subject to postmortem examination at 14 days after dosing. Abnormal signs or lesions that could be attributed to clorsulon were not found in any goat.

• Authors: S F Sundlof, E L Bliss, E C Greiner, T Q Tran, M A Wertenberger
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 52 Issue 1 Pg. 111-4 (Jan 1991) ISSN: 0002-9645 [Print] United States
• PMID: 2021237 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antiplatyhelmintic Agents
• Sulfanilamides
• clorsulon

Topics

• Animals
• Antiplatyhelmintic Agents (administration & dosage, adverse effects, therapeutic use)
• Fasciola hepatica (drug effects)
• Fascioliasis (drug therapy, etiology, parasitology, veterinary)
• Female
• Goat Diseases (drug therapy, etiology, parasitology)
• Goats
• Male
• Sulfanilamides (administration & dosage, adverse effects, therapeutic use)