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Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.

Abstract
A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out.
AuthorsOzair Alam, Pooja Mullick, S P Verma, Sadaf J Gilani, Suroor A Khan, Nadeem Siddiqui, Waquar Ahsan
JournalEuropean journal of medicinal chemistry (Eur J Med Chem) Vol. 45 Issue 6 Pg. 2467-72 (Jun 2010) ISSN: 1768-3254 [Electronic] France
PMID20211511 (Publication Type: Journal Article)
CopyrightCopyright (c) 2010 Elsevier Masson SAS. All rights reserved.
Chemical References
  • Anticonvulsants
  • Pyrimidines
  • Semicarbazones
  • pyrimidine
Topics
  • Animals
  • Anticonvulsants (chemical synthesis, chemistry, pharmacology, toxicity)
  • Drug Evaluation, Preclinical (methods)
  • Drug Synergism
  • Epilepsy (drug therapy)
  • Liver (drug effects, enzymology, metabolism)
  • Mice
  • Nervous System (drug effects)
  • Pyrimidines (chemistry)
  • Semicarbazones (chemical synthesis, chemistry, pharmacology, toxicity)

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