Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway.

Abstract

Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on pro-inflammatory NF-kappaB activation via the redox-related NIK/IKK and MAPK pathways. Action mechanism of zingerone on NF-kappaB signaling was investigated in aged rat kidney and endothelial cells. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-kappaB activation in aged rat. In addition, zingerone treatment suppressed gene activation of pro-inflammatory enzymes, COX-2 and iNOS, which were upregulated with aging through NF-kappaB activation and IKK/MAPK signaling pathway. These experiments strongly indicate that zingerone treatment exerts a beneficial efficacy by suppressing both oxidative stress and age-related inflammation through the modulation of several key pro-inflammatory genes and transcription factors. Thus, the significance of our findings is that the zingerone treatment may provide some preventive measure against chronic inflammatory conditions that underlie many age-related inflammatory diseases, such as metabolic syndrome, cardiovascular disease, dementia, arthritis, diabetes, osteoprosis, and cancers.

• Authors: Mi Kyung Kim, Sang Woon Chung, Dae Hyun Kim, Ji Min Kim, Eun Kyeong Lee, Ji Young Kim, Young Mi Ha, Yun Hee Kim, Jae-Kyung No, Hye Sun Chung, Kun-Young Park, Sook Hee Rhee, Jae Sue Choi, Byung Pal Yu, Takako Yokozawa, Young Jin Kim, Hae Young Chung
• Journal: Experimental gerontology (Exp Gerontol) Vol. 45 Issue 6 Pg. 419-26 (Jun 2010) ISSN: 1873-6815 [Electronic] England
• PMID: 20211236 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: 2010 Elsevier Inc. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• NF-kappa B
• Reactive Oxygen Species
• zingerone
• Guaiacol
• Nitric Oxide Synthase Type II
• Mitogen-Activated Protein Kinases

Topics

• Aging (drug effects, metabolism)
• Animals
• Anti-Inflammatory Agents (pharmacology)
• Antioxidants (pharmacology)
• Blotting, Western
• Caloric Restriction
• Guaiacol (analogs & derivatives, pharmacology)
• Humans
• Inflammation (metabolism)
• MAP Kinase Signaling System (drug effects, physiology)
• Mitogen-Activated Protein Kinases (drug effects, metabolism)
• NF-kappa B (metabolism, pharmacology)
• Nitric Oxide Synthase Type II
• Oxidation-Reduction (drug effects)
• Oxidative Stress (drug effects)
• Rats
• Rats, Inbred F344
• Reactive Oxygen Species (metabolism)