[Features of allele polymorphism of genes involved in homocysteine and folate metabolism in patients with atherosclerosis of the lower extremity arteries].

Abstract

Under study were features of allele polymorphism of genes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A 2756G), methionine synthase reductase (MTRR A66G) and methylenetetrahydrofolate dehydrogenase (MTHFD G1958A) in patients with atherosclerosis of the lower extremity arteries (ALEA). Patients with hyperhomocysteinemia (HHcy) had statistically significant increase of allele MTHFR 677T and MTRR 66GG as compared both with the control group and with the group of patients without HHcy. It suggests that polymorphism of genes involved in homocystein and folate metabolism might affect the risk of HHcy in patients with ALEA.

• Authors: N A Klenkova, S I Kapustin, N B Saltykova, V M Shmeleva, M N Blinov
• Journal: Vestnik khirurgii imeni I. I. Grekova (Vestn Khir Im I I Grek) Vol. 168 Issue 6 Pg. 41-4 ( 2009) ISSN: 0042-4625 [Print] Russia (Federation)
• PMID: 20209990 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Flavoproteins
• Homocysteine
• 5,11-methenyltetrahydrohomofolate
• DNA
• Folic Acid
• methionine synthase reductase
• Ferredoxin-NADP Reductase

Topics

• Alleles
• Atherosclerosis (blood, diagnosis, genetics)
• DNA (genetics)
• Female
• Ferredoxin-NADP Reductase (genetics)
• Flavoproteins
• Folic Acid (analogs & derivatives, blood, genetics)
• Follow-Up Studies
• Genetic Predisposition to Disease
• Genotype
• Homocysteine (blood, genetics)
• Humans
• Leg (blood supply)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Prognosis
• Severity of Illness Index