Abstract |
PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) is a rare clinical syndrome characterized by the presence of tics, Tourette syndrome, obsessive-compulsive disorder, or chorea in the context of an immediately precedent streptococcal infection. In this report, we describe the case of an 11-year-old boy who developed PANDAS with severe choreic movements. The criteria for PANDAS diagnosis were met. Moreover, serum antibrain antibodies were present. The patient was initially treated with tetrabenazine 12.5 mg twice daily with remission of the neurological symptoms. Subsequently, the patient underwent tonsillectomy and has been asymptomatic since, with antistreptolysin O titer levels in range.
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Authors | Francesca Romana Fusco, Alessandra Pompa, Giorgio Bernardi, Fabrizio Ottaviani, Carmela Giampà, Daunia Laurenti, Maria Morello, Sergio Bernardini, Marzia Nuccetelli, Umberto Sabatini, Stefano Paolucci |
Journal | Journal of child neurology
(J Child Neurol)
Vol. 25
Issue 5
Pg. 614-5
(May 2010)
ISSN: 1708-8283 [Electronic] United States |
PMID | 20207613
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Dyskinesia Agents
- Autoantibodies
- Antistreptolysin
- Tetrabenazine
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Topics |
- Anti-Dyskinesia Agents
(therapeutic use)
- Antistreptolysin
(blood)
- Autoantibodies
(blood)
- Autoimmune Diseases of the Nervous System
(drug therapy, surgery, therapy)
- Brain
(immunology)
- Child
- Chorea
(drug therapy, surgery, therapy)
- Combined Modality Therapy
- Humans
- Male
- Mental Disorders
(drug therapy, surgery, therapy)
- Streptococcal Infections
(drug therapy, surgery, therapy)
- Syndrome
- Tetrabenazine
(therapeutic use)
- Tonsillectomy
(methods)
- Treatment Outcome
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