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Hypersensitivity vasculitis with leukocytoclastic vasculitis associated with alpha-1-proteinase inhibitor.

Abstract
Prolastin is a commercially available form of alpha-1-antitrypsin (AAT) that is derived from pooled human plasma and used for treatment of severe alpha-1-antitrypsin deficiency (AATD). We describe a patient with AATD who developed presumed hypersensitivity vasculitis (HV) following a Prolastin infusion. Hypersensitivity vasculitis (HV), or cutaneous vasculitis, is characterized by inflammation of the small vessels of the skin with resultant ischemia to the distally supplied areas. To our knowledge, this is the first reported case of presumed hypersensitivity vasculitis following Prolastin infusion.
AuthorsNicola W Mwirigi, Charles F Thomas
JournalCase reports in medicine (Case Rep Med) Vol. 2009 Pg. 941258 ( 2009) ISSN: 1687-9635 [Electronic] United States
PMID20204065 (Publication Type: Case Reports)

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