Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold.

Abstract

A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.

• Authors: Lun K Tsou, Ginger E Dutschman, Elizabeth A Gullen, Maria Telpoukhovskaia, Yung-Chi Cheng, Andrew D Hamilton
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 20 Issue 7 Pg. 2137-9 (Apr 01 2010) ISSN: 1464-3405 [Electronic] England
• PMID: 20202840 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Antiviral Agents
• Calixarenes

Topics

• Antiviral Agents (chemistry, pharmacology)
• Calixarenes (chemistry, pharmacology)
• Cell Line
• Cell Survival (drug effects)
• HIV (drug effects)
• HIV Infections (drug therapy)
• Hepacivirus (drug effects)
• Hepatitis C (drug therapy)
• Inhibitory Concentration 50
• Models, Molecular
• Molecular Structure