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[In vitro Ingavirin efficacy against adenoviral infection pathogen].

Abstract
The experimental investigation of the Ingavirin antiviral effect showed that in concentrations of 200 and 100 mcg/ml it totally protected the cells from the cytopathic action of the virus, when added before the inoculation of the HeLa cell culture. After a tenfold decrease of the infective dose (up to 0.001 CPD50/cell), the inhibition of the virus cytopathic effect by Ingavirin amounted to 100% in all the tested concentrations (including the low ones) added either before or after the culture contamination. Ingavirin was efficient in inhibition of the adenovirus type 5 reproduction in the HeLa cell culture.
AuthorsS Ia Loginova, S V Borisevich, V A Maksimov, V P Bondarev, V E Nebol'sin
JournalAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 54 Issue 7-8 Pg. 16-8 ( 2009) ISSN: 0235-2990 [Print] Russia (Federation)
PMID20201398 (Publication Type: Journal Article)
Chemical References
  • Amides
  • Antiviral Agents
  • Caproates
  • Dicarboxylic Acids
  • Imidazoles
  • pentanedioic acid imidazolyl ethanamide
Topics
  • Adenovirus Infections, Human (virology)
  • Adenoviruses, Human (drug effects, physiology)
  • Amides (pharmacology)
  • Antiviral Agents (pharmacology)
  • Caproates
  • Cytopathogenic Effect, Viral (drug effects)
  • Dicarboxylic Acids (pharmacology)
  • HeLa Cells
  • Humans
  • Imidazoles (pharmacology)
  • Virus Replication (drug effects)

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