Abstract |
The experimental investigation of the Ingavirin antiviral effect showed that in concentrations of 200 and 100 mcg/ml it totally protected the cells from the cytopathic action of the virus, when added before the inoculation of the HeLa cell culture. After a tenfold decrease of the infective dose (up to 0.001 CPD50/cell), the inhibition of the virus cytopathic effect by Ingavirin amounted to 100% in all the tested concentrations (including the low ones) added either before or after the culture contamination. Ingavirin was efficient in inhibition of the adenovirus type 5 reproduction in the HeLa cell culture.
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Authors | S Ia Loginova, S V Borisevich, V A Maksimov, V P Bondarev, V E Nebol'sin |
Journal | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]
(Antibiot Khimioter)
Vol. 54
Issue 7-8
Pg. 16-8
( 2009)
ISSN: 0235-2990 [Print] Russia (Federation) |
PMID | 20201398
(Publication Type: Journal Article)
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Chemical References |
- Amides
- Antiviral Agents
- Caproates
- Dicarboxylic Acids
- Imidazoles
- pentanedioic acid imidazolyl ethanamide
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Topics |
- Adenovirus Infections, Human
(virology)
- Adenoviruses, Human
(drug effects, physiology)
- Amides
(pharmacology)
- Antiviral Agents
(pharmacology)
- Caproates
- Cytopathogenic Effect, Viral
(drug effects)
- Dicarboxylic Acids
(pharmacology)
- HeLa Cells
- Humans
- Imidazoles
(pharmacology)
- Virus Replication
(drug effects)
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