To asses the effects of rocuronium pretreatment on succinylcholine induced fasciculations and postoperative myalgias.

Abstract

OBJECTIVE:

To asses the effects of Rocuronium pretreatment on Succinylcholine induced Fasciculations and postoperative Myalgias.

METHODS:

A randomized double blind case control study was conducted in Department of Anaesthesia and Surgical Intensive Care Unit, Liaquat National Hospital, Karachi from October 2003 - April 2004. Sixty adults ASA I or II patients who presented for elective general surgical procedures were included in the study. The patients were divided in two groups of thirty each by a simple lottery method. Group "A" received placebo and group "B" received Rocuronium 0.1 mg/kg, one minute prior to induction with Pentothal Sodium 5 mg/kg, Suxamethonium, 1.5 mg/kg and Nalbuphine 10 mg / 70 kg. Fasciculations and intubation condition was assessed immediately after the induction of anaesthesia while post operative myalgias were assessed 6, 12 and 24 hours after surgery.

RESULTS:

Fasciculations were noticed in group "A" as 100% (mild to severe) and in group "B" 13.3% (mild). Post operative myalgias at 6 and 12 hours after surgery were 76.66 % in group "A" and 16.66 in groups "B". After 24 hours in group "A' post operative myalgias were 93.33% and group "B" 23.33%.

CONCLUSION:

It is concluded that pretreatment with Rocuronium reduced the incidence of myalgias, fasciculations and produced rapid precurarization in one minute thereby saving time on busy operating lists. They also allowed the early ambulation of patients in minor surgeries.

• Authors: Nighat Abbas, Sabahat Tariq, Akhtar Waheed Khan, Ghulam Murtaza, Nadeem Naqvi, Arshad Khanzada
• Journal: JPMA. The Journal of the Pakistan Medical Association (J Pak Med Assoc) Vol. 59 Issue 12 Pg. 847-50 (Dec 2009) ISSN: 0030-9982 [Print] Pakistan
• PMID: 20201179 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Androstanols
• Neuromuscular Depolarizing Agents
• Neuromuscular Nondepolarizing Agents
• Succinylcholine
• Rocuronium

Topics

• Adolescent
• Adult
• Androstanols (therapeutic use)
• Double-Blind Method
• Fasciculation (prevention & control)
• Female
• Humans
• Male
• Middle Aged
• Muscular Diseases (prevention & control)
• Neuromuscular Depolarizing Agents (adverse effects)
• Neuromuscular Nondepolarizing Agents (therapeutic use)
• Pain, Postoperative (prevention & control)
• Rocuronium
• Succinylcholine (adverse effects)
• Young Adult