Abstract |
We investigated changes in drug disposition and toxicities with CPT-11 in 15 dialysis patients with gastrointestinal cancers to clarify whether CPT-11 could be administered safely in such patients. For comparison, the same parameters were also investigated in 10 cancer patients not undergoing dialysis. Items investigated included (1) plasma concentrations of SN-38, SN-38G and CPT-11 at 0, 1, 12, 24, 36, 48 and 72 h after administration, together with a comparison of mean AUC values for 3 dose levels of CPT-11 (50, 60 and 70 mg/m2) in dialysis patients and controls; and (2) occurrence of adverse events. Several findings emerged from this study: (1) No significant difference was observed in the AUC for SN-38 or CPT-11 between the dialysis and control groups; (2) The AUC for SN-38G at each dose was significantly higher in dialysis patients; and (3) Grade 1-4 leucopenia was observed in 11 of the dialysis patients. One patient developed grade 4 leucopenia and died due to sepsis. Anorexia, diarrhea, nausea, alopecia and interstitial pneumonia occurred in 6 dialysis patients. We found changes in drug dispositions of CPT-11, SN-38 and SN-38G in dialysis patients, suggesting that hepatic excretion, especially that of SN-38G, was increased. No significant difference in occurrence of adverse events was observed between the 2 groups. This indicates that CPT-11 can be administered safely in patients on dialysis.
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Authors | Tatsuto Ashizawa, Tohru Iwahori, Takayoshi Yokoyama, Yuu Kihara, Osamu Konnno, Yoshimaro Jyojima, Isao Akashi, Yuuki Nakamura, Kouichirou Hama, Hitoshi Iwamoto, Mai Segawa, Hironori Takeuchi, Toshihiko Hirano, Takeshi Nagao |
Journal | Acta medica Okayama
(Acta Med Okayama)
Vol. 64
Issue 1
Pg. 19-26
(Feb 2010)
ISSN: 0386-300X [Print] Japan |
PMID | 20200580
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Irinotecan
- Camptothecin
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Topics |
- Aged
- Aged, 80 and over
- Antineoplastic Agents, Phytogenic
(administration & dosage, adverse effects, blood)
- Camptothecin
(administration & dosage, adverse effects, analogs & derivatives, blood)
- Colorectal Neoplasms
(complications, drug therapy)
- Female
- Gastrointestinal Neoplasms
(complications, drug therapy)
- Humans
- Irinotecan
- Kidney Failure, Chronic
(complications, therapy)
- Leukopenia
(chemically induced)
- Male
- Middle Aged
- Rectal Neoplasms
(complications, drug therapy)
- Renal Dialysis
- Stomach Neoplasms
(complications, drug therapy)
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