Abstract | CONTEXT: OBJECTIVE: The objective of the study was to determine whether rs2016520 or other single-nucleotide polymorphism in the PPARD locus influenced the risk of developing various characteristics of metabolic disease. DESIGN: Haplotype tagging analysis across PPARD was performed in 11,074 individuals from the Welcome Trust U.K. Type 2 Diabetes Case Control Collection. RESULTS: CONCLUSION: The current results suggest differential effects of PPARdelta in males and females.
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Authors | Lindsay R Burch, Louise A Donnelly, Alex S F Doney, Jeffrey Brady, Anna M Tommasi, Adrian L Whitley, Catharine Goddard, Andrew D Morris, Michael K Hansen, Colin N A Palmer |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 95
Issue 4
Pg. 1830-7
(Apr 2010)
ISSN: 1945-7197 [Electronic] United States |
PMID | 20200337
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Leptin
- Lipids
- PPAR delta
- Tumor Necrosis Factor-alpha
- Cholesterol
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Topics |
- Adiponectin
(blood)
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Body Mass Index
- Cholesterol
(blood)
- Cohort Studies
- Diabetes Mellitus, Type 2
(blood, genetics, metabolism)
- Female
- Gene Frequency
- Genotype
- Haplotypes
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Hyperlipidemias
(drug therapy, genetics)
- Leptin
(blood)
- Lipids
(blood)
- Male
- Middle Aged
- PPAR delta
(genetics, metabolism)
- Phenotype
- Polymorphism, Single Nucleotide
(genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Sex Characteristics
- Tumor Necrosis Factor-alpha
(blood)
- Young Adult
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