A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses.

Abstract	The formylpeptide receptor-like 1, now officially termed FPR2, in human and its mouse homolog mFPR2 mediate leukocyte migration in response to agonists associated with inflammation and immune responses. To clarify the in vivo role of the receptor, we generated mice deficient in mFPR2. mFPR2(-/-) mice showed markedly reduced severity in OVA/alum-induced allergic airway inflammation. This was associated with diminished recruitment of CD11c(+) dendritic cells into the airway mucosa and secondary lymphoid organs, as well as reduced production of Type 2 cytokines and Igs. We also found that the bronchoalveolar lavage fluid from wild type mice with airway inflammation contained mFPR2 agonist activity. This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses.
Authors	Keqiang Chen, Yingying Le, Ying Liu, Wanghua Gong, Guoguang Ying, Jian Huang, Teizo Yoshimura, Lino Tessarollo, Ji Ming Wang
Journal	Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 184 Issue 7 Pg. 3331-5 (Apr 01 2010) ISSN: 1550-6606 [Electronic] United States
PMID	20200280 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)
Chemical References	Allergens Alum Compounds Cytokines Receptors, Formyl Peptide formyl peptide receptor 2, mouse aluminum sulfate Ovalbumin
Topics	Allergens (immunology, pharmacology) Alum Compounds (pharmacology) Animals Bronchoalveolar Lavage Fluid (chemistry, immunology) Cell Separation Chemotaxis, Leukocyte (immunology) Cytokines (analysis, biosynthesis, immunology) Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Hypersensitivity (immunology) Immunohistochemistry Inflammation (immunology, pathology) Lung (immunology, pathology) Mice Mice, Inbred C57BL Mice, Knockout Ovalbumin (immunology, pharmacology) Receptors, Formyl Peptide (immunology) Respiratory Hypersensitivity (immunology, pathology) Reverse Transcriptase Polymerase Chain Reaction

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