Systematized contact dermatitis and montelukast in an atopic boy.

Abstract

Upon ingestion, the artificial sweetener, aspartame is metabolized to formaldehyde in the body and has been reportedly associated with systemic contact dermatitis in patients exquisitely sensitive to formaldehyde. We present a case of a 9-year-old Caucasian boy with a history of mild atopic dermatitis that experienced severe systematized dermatitis after being started on montelukast chewable tablets containing aspartame. Patch testing revealed multiple chemical sensitivities which included a positive reaction to formaldehyde. Notably, resolution of his systemic dermatitis only occurred with discontinuation of the montelukast chewables.

• Authors: Mari Paz Castanedo-Tardan, Mercedes E González, Elizabeth A Connelly, Kelly Giordano, Sharon E Jacob
• Journal: Pediatric dermatology (Pediatr Dermatol) 2009 Nov-Dec Vol. 26 Issue 6 Pg. 739-43 ISSN: 1525-1470 [Electronic] United States
• PMID: 20199453 (Publication Type: Case Reports, Journal Article)

Chemical References

• Acetates
• Anti-Asthmatic Agents
• Cyclopropanes
• Dermatologic Agents
• Quinolines
• Sulfides
• Sweetening Agents
• hydrocortisone-17-butyrate
• montelukast
• Hydrocortisone
• Aspartame

Topics

• Acetates (adverse effects)
• Anti-Asthmatic Agents (adverse effects)
• Aspartame (adverse effects)
• Asthma (drug therapy)
• Chemistry, Pharmaceutical
• Child
• Cyclopropanes
• Dermatitis, Contact (drug therapy, etiology, pathology)
• Dermatologic Agents (administration & dosage)
• Humans
• Hydrocortisone (administration & dosage, analogs & derivatives)
• Male
• Quinolines (adverse effects)
• Sulfides
• Sweetening Agents (adverse effects)