Monoclonal antibody MG7 as a screening tool for gastric cancer.

Abstract

MG7 is a gastric cancer-specific MAb with high specificity and sensitivity. By using MG7 MAb, we found that MG7Ag was increasingly detected in superficial gastritis, atrophic gastritis, intestinal metaplasia, atypical hyperplasia, and gastric cancer, indicating that MG7Ag could be considered an important early warning molecule of gastric cancer and MG7 MAb could be used as a tool for screening gastric cancer. We have developed a new and sensitive system, immuno-realtime PCR, for detection of MG7Ag in the serum. The use of qIPCR assays enabled the detection of MG7Ag in complex biological samples that were poorly accessible by conventional immunoassays.

• Authors: Zheng Chen, Liu Hong, Lin Liu, Daorong Peng, Quanjiang Li, Bin Jin, Taidong Qiao, Kaichun Wu, Daiming Fan
• Journal: Hybridoma (2005) (Hybridoma (Larchmt)) Vol. 29 Issue 1 Pg. 27-30 (Feb 2010) ISSN: 1557-8348 [Electronic] United States
• PMID: 20199148 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antigens, Neoplasm
• Biomarkers, Tumor
• MG7 antigen, human
• MG7 monoclonal antibody

Topics

• Antibodies, Monoclonal (immunology)
• Antigens, Neoplasm (immunology)
• Biomarkers, Tumor (immunology, metabolism)
• Enzyme-Linked Immunosorbent Assay
• Gastritis (blood, diagnosis, immunology)
• Humans
• Hyperplasia (blood, diagnosis, immunology)
• Immunoenzyme Techniques
• Metaplasia (blood, diagnosis, immunology)
• Plasmids
• Polymerase Chain Reaction
• Precancerous Conditions (blood, diagnosis, immunology)
• Stomach Neoplasms (blood, diagnosis, immunology)