Abstract |
Blocking or impairment of the sphenopalatine ganglia (SPG) is an effective therapy of cluster headache and other pain syndromes. Contrarily, unilateral SPG-stimulation reduces infarction size in the rat permanent suture model. Well, what are the effects of the SPG damage on the following brain ischemia? This study was aimed to investigate the effects of resection of the nerves bundle from the SPG of rat on the brain lesions following middle cerebral artery occlusion (MCAO), and evaluated the roles of the nitric oxygen synthase (NOS) immunoreactive perivascular nerves of cerebral arteries in MCAO. We found that 7 days after bilateral resections of the nerves bundle from the SPG, the NOS activity perivascular nerves in the middle cerebral arteries disappeared, and the infarction volume and the TUNEL positive cells increased significantly after 24 h MCAO, which implicated that the NOS contained nerves from the SPG maybe have an important role in the MCAO.
|
Authors | Su Diansan, Zhang Shifen, Gu Zhen, Wang Heming, Wang Xiangrui |
Journal | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
(Neurol Sci)
Vol. 31
Issue 4
Pg. 431-5
(Aug 2010)
ISSN: 1590-3478 [Electronic] Italy |
PMID | 20198495
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Nitric Oxide Synthase
- NADPH Dehydrogenase
|
Topics |
- Animals
- Brain Ischemia
(pathology)
- Cell Count
- Ganglia, Parasympathetic
(enzymology, surgery)
- Immunohistochemistry
- In Situ Nick-End Labeling
- Infarction, Middle Cerebral Artery
(enzymology, pathology)
- Ligation
- Middle Cerebral Artery
(enzymology, innervation, pathology)
- NADPH Dehydrogenase
(metabolism)
- Nerve Fibers
(enzymology)
- Nitric Oxide Synthase
(metabolism)
- Rats
- Rats, Sprague-Dawley
|