Synthesis, characterization, and biological screening of a copper flurbiprofen complex with anti-inflammatory effects.

Abstract

The flurbiprofen complex of copper(II) was prepared and characterized by IR, UV-VIS and EPR Spectroscopy, magnetic susceptibility, and thermogravimetric analysis. The compound was tested for in vivo anti-inflammatory and analgesic activities in rats. The inhibitory effect on carrageenin-induced paws inflammation and analgesic effect of copper flurbiprofen complex were similar to those of free flurbiprofen. However, the copper complex produced less gastric irritation than the parent drug.

• Authors: S Oga, S F Taniguchi, R Najjar, A R Souza
• Journal: Journal of inorganic biochemistry (J Inorg Biochem) Vol. 41 Issue 1 Pg. 45-51 (Jan 1991) ISSN: 0162-0134 [Print] United States
• PMID: 2019832 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• copper flurbiprofen complex
• Flurbiprofen

Topics

• Analysis of Variance
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (chemical synthesis)
• Edema (drug therapy)
• Flurbiprofen (chemical synthesis, chemistry, pharmacology)
• Gastric Mucosa (drug effects, physiology)
• Intestinal Mucosa (drug effects, physiology)
• Male
• Molecular Structure
• Rats
• Rats, Inbred Strains
• Spectrophotometry, Infrared