Abstract |
HE3286 (17alpha-ethynyl-5-androstene-3beta, 7beta, 17beta-triol) is an orally bio-available synthetic derivative of naturally occurring androstene-3beta, 7beta, 17beta-triol. Our present data show that oral treatment with HE3286, favourably influenced the course of arthritis in the rat model of adjuvant-induced arthritis (reduced cumulative disease scores and paw edema), and in the mouse model of collagen antibody-induced arthritis (reduced clinical paw scores). Importantly, HE3286 was not immune suppressive in human mixed lymphocyte reaction or in animals challenged with Coxsackie B3 virus. HE3286 is currently in phase I/II clinical trials in rheumatoid arthritis and ulcerative colitis and these findings further strengthen the possibility that HE3286 may represent an effective anti-inflammatory agent useful for treating chronic inflammation with a more attractive safety profile than glucocorticoids or cyclooxygenase inhibitors.
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Authors | Dominick L Auci, Katia Mangano, Daniel Destiche, Steven K White, Yujin Huang, David Boyle, James Frincke, Christopher L Reading, Ferdinando Nicoletti |
Journal | International journal of molecular medicine
(Int J Mol Med)
Vol. 25
Issue 4
Pg. 625-33
(Apr 2010)
ISSN: 1791-244X [Electronic] Greece |
PMID | 20198312
(Publication Type: Journal Article)
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Chemical References |
- 17-ethynyl-5-androstene-3, 7, 17-triol
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Dehydroepiandrosterone
- Peroxidase
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Topics |
- Administration, Oral
- Animals
- Arthritis, Experimental
(blood, drug therapy, enzymology, pathology)
- Arthritis, Rheumatoid
(blood, drug therapy, enzymology, pathology)
- Body Weight
- Dehydroepiandrosterone
(administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
- Disease Models, Animal
- Disease Progression
- Enterovirus B, Human
(physiology)
- Humans
- Immunization
- Interleukin-6
(blood)
- Lymphocyte Culture Test, Mixed
- Male
- Mice
- Myocarditis
(drug therapy, virology)
- Organ Size
- Peroxidase
(metabolism)
- Rats
- Time Factors
- Tumor Necrosis Factor-alpha
(blood)
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