Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico.

Abstract

This study evaluated the association of -401C/T and +452C/T polymorphisms of gamma-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the -401C/T polymorphism and the risk of relapse was found (p=0.028), patients with the -401T/T genotype have 10.83 (95% CI 1.30-90.14) more chance of a relapse of leukemia. No association was found between the +452C/T polymorphism and the risk of relapse. Therefore, our investigation suggests that the -401C/T polymorphism in the gamma-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with ALL.

• Authors: Jorge Organista-Nava, Yazmín Gómez-Gómez, Mónica Virginia Saavedra-Herrera, Ana Bertha Rivera-Ramírez, Marco Antonio Terán-Porcayo, Luz Del Carmen Alarcón-Romero, Berenice Illades-Aguiar, Marco Antonio Leyva-Vázquez
• Journal: Leukemia research (Leuk Res) Vol. 34 Issue 6 Pg. 728-32 (Jun 2010) ISSN: 1873-5835 [Electronic] England
• PMID: 20197200 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 Elsevier Ltd. All rights reserved.

Chemical References

• Antimetabolites, Antineoplastic
• gamma-Glutamyl Hydrolase
• Methotrexate

Topics

• Adolescent
• Antimetabolites, Antineoplastic (adverse effects, therapeutic use)
• Case-Control Studies
• Child
• Child, Preschool
• Female
• Gene Frequency
• Genotype
• Humans
• Infant
• Male
• Methotrexate (adverse effects, therapeutic use)
• Mexico
• Polymorphism, Single Nucleotide (physiology)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, genetics, pathology)
• Recurrence
• Risk
• Treatment Outcome
• gamma-Glutamyl Hydrolase (genetics)