Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia.

Abstract

The objective of this study was to determine the association of 5-HT2C (serotonin 2C receptor) and MDR1 (multidrug resistant protein) genetic polymorphisms and antipsychotic-induced metabolic abnormalities among female patients with DSM IV schizophrenia spectrum disorders. We have previously reported the associations of -759CT 5-HT2C and G2677T and C3435T MDR1 genetic polymorphisms and olanzapine/risperidone-induced weight gain in a similar sample of patients. Here, we included a total of 101 previously non-medicated female patients treated with olanzapine/risperidone over a 3-month period. The variables analyzed included fasting glucose, total cholesterol, low-density lipoprotein, high-density lipoprotein and triglyceride levels in blood, blood pressure and waist circumferences. We observed significant association of -759T 5-HT2C genetic variant and greater increase in waist circumference (P=0.03), fasting glucose level (P=0.046) and triglyceride level (P=0.045) in blood after a 3-month period. The 2677T and 3435T MDR1 genetic variants were significantly associated with the greater increase in fasting glucose level in blood when patients were using olanzapine (P<0.001 and P=0.028, respectively). Our data indicate a possible influence of -759CT 5-HT2C and MDR1 G2677T and C3435T MDR1 genetic polymorphisms on the development of metabolic abnormalities among female patients treated with olanzapine/risperidone.

• Authors: M R Kuzman, V Medved, N Bozina, J Grubišin, N Jovanovic, J Sertic
• Journal: The pharmacogenomics journal (Pharmacogenomics J) Vol. 11 Issue 1 Pg. 35-44 (Feb 2011) ISSN: 1473-1150 [Electronic] United States
• PMID: 20195292 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ABCB1 protein, human
• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Antipsychotic Agents
• Blood Glucose
• Receptor, Serotonin, 5-HT2C
• Benzodiazepines
• Risperidone
• Olanzapine

Topics

• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1 (genetics, metabolism)
• Adult
• Antipsychotic Agents (adverse effects, therapeutic use)
• Benzodiazepines (adverse effects, therapeutic use)
• Blood Glucose (metabolism)
• Cohort Studies
• Female
• Humans
• Middle Aged
• Olanzapine
• Polymorphism, Genetic
• Receptor, Serotonin, 5-HT2C (genetics, metabolism)
• Risperidone (adverse effects, therapeutic use)
• Schizophrenia (drug therapy, genetics, metabolism)
• Waist Circumference
• Young Adult