[A 1:2 matched case-control study on the interaction of HPV16E6 and HLA-DR9 allele to esophageal cancer in Kazakh ethnicity, Xinjiang].

Abstract

OBJECTIVE:

To evaluate the role and the association between HPV16E6 infection and HLA-DR9 immune-associated gene to esophageal cancer (EC) in Kazakh of Xinjiang, China.

METHODS:

A 1:2 matched case-control study was conducted with 63 cases of EC and 126 controls involved. The controls were matched by sex, nationality, area of residence and age within 5-year difference. HPV16E6 and HLA-DR9 allele were identified by PCR-SSP. Interaction was performed to identify risk factors.

RESULTS:

HPV16E6 infection and HLA-DR9 allele positive status were the risk factors for EC, with OR values as 2.67 (95%CI: 1.38 - 5.17) and 3.83 (95%CI: 1.48 - 9.96) respectively. The rate of HPV16E6 infection in individuals with HLA-DR9 allele was different from the ones who were HLA-DR9 allele free (chi(2) = 7.57, P = 0.006), with OR value as 5.79 (95%CI: 1.53 - 21.87). In the controls, the rates of HPV16E6 infection were 22.2% and 16.2% among individuals with HLA-DR9 allele atatus as positive or negative, and without statistically significant difference. Interaction analysis showed there was an interaction of HPV16E6 with HLA-DR9 and were higher than the sum of the two factors presented individually.

CONCLUSION:

In our study, we found that the HLA-DR9 allele and HPV16E6 infection had a function of synergy in the process of malignant transformation of esophageal epithelial cells, and jointly promoting the occurrence and development of EC.

• Authors: Pei-hua Liao, Jiang-mei Qin, Tong-xia Zeng, Feng Li, Jin-feng Cai, Ling He
• Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi (Zhonghua Liu Xing Bing Xue Za Zhi) Vol. 30 Issue 9 Pg. 951-4 (Sep 2009) ISSN: 0254-6450 [Print] China
• PMID: 20193235 (Publication Type: English Abstract, Journal Article)

Chemical References

• E6 protein, Human papillomavirus type 16
• HLA-DR Antigens
• HLA-DR Serological Subtypes
• HLA-DR9 antigen
• Oncogene Proteins, Viral
• Repressor Proteins

Topics

• Alleles
• Case-Control Studies
• Cell Transformation, Neoplastic (genetics)
• China (epidemiology)
• Epithelial Cells (pathology)
• Esophageal Neoplasms (ethnology, etiology, genetics)
• Esophagus (pathology)
• HLA-DR Antigens (genetics)
• HLA-DR Serological Subtypes
• Humans
• Oncogene Proteins, Viral
• Papillomavirus Infections (complications)
• Polymerase Chain Reaction
• Repressor Proteins
• Risk Factors